INJECTABLES
Polynucleotides
An advanced regenerative injectable treatment designed to support skin repair, hydration and natural rejuvenation from within.
At Sapphire Medical Aesthetics, polynucleotides are used to help improve skin quality, texture, elasticity and radiance. This treatment works beneath the surface of the skin to create the right conditions for renewal, helping tired, delicate or ageing skin look fresher, healthier and more resilient over time.
Polynucleotides
Regenerate skin from within
what are polynucleotides
Polynucleotides are injectable biostimulating molecules that help support the skin’s natural repair processes. Often described as a regenerative skin treatment, they work by encouraging fibroblast activity, helping to support collagen and elastin production, hydration and tissue repair.
Unlike treatments that simply add volume, polynucleotides focus on improving the quality and behaviour of the skin itself. They can be especially helpful for skin that feels dull, dehydrated, crepey, fragile or affected by ageing, inflammation or loss of elasticity.
At Sapphire, polynucleotides are used as part of a considered, skin-first approach. The goal is not to change your features, but to support healthier, smoother and more luminous skin from within.
Treatment Time
Approx. 30–45 minutes
Best For
Skin repair, hydration and elasticity
Results
Gradual skin renewal from within
Ideal For Treating
Polynucleotides may be suitable for:
Fine lines and wrinkles
Dull or dehydrated skin
Loss of elasticity
Crepey or thinning skin
Under-eye skin quality
Dark circles and tired-looking eyes
Skin inflammation and redness
Acne scarring
Sun-damaged skin
Neck, décolletage and hand rejuvenation
Overall skin regeneration and glow
Polynucleotides can be used on areas such as the face, under-eyes, neck, décolletage, hands and scalp, depending on the product used and your individual treatment plan.
How It Works
Your treatment begins with a consultation to assess your skin quality, concerns, medical history and suitability. Our Nurses will look at the areas you would like to improve and advise whether polynucleotides are the most appropriate option for your skin goals.
Polynucleotides are placed into the skin using a series of small injections. Once injected, they help support the skin’s regenerative environment by encouraging repair, hydration and collagen-related activity. This can help improve skin texture, elasticity and overall resilience over time.
Results are gradual rather than instant. Many patients notice early skin improvement after a course of treatment, with results continuing to build as the skin responds. Treatment is usually recommended as a series of sessions, often spaced a few weeks apart, with maintenance advised depending on your skin and long-term goals. Clinical and aesthetic sources commonly describe courses of around 2–4 sessions, with maintenance often considered around 6–12 months.
Safety and Expertise
Medical expertise, regenerative skin results
Polynucleotides are a specialist injectable treatment and should be carried out by an experienced practitioner with a strong understanding of skin, anatomy and injectable technique.
At Sapphire Medical Aesthetics, treatment is planned carefully around your individual skin needs. Your Nurse will assess your suitability, explain what to expect and advise whether polynucleotides should be used alone or as part of a wider treatment plan.
As with any injectable treatment, temporary redness, swelling, tenderness, bruising or small bumps at the injection points can occur. Because many polynucleotide products are derived from fish DNA, suitability should also be carefully assessed for anyone with relevant allergies or sensitivities.
The Sapphire Approach - Skin Regeneration
At Sapphire, polynucleotides are used for patients who want to improve skin quality in a subtle, regenerative way.
This treatment is not about creating instant volume or changing the face. It is about strengthening the skin, supporting repair and helping it behave more youthfully over time. For the right patient, polynucleotides can be a beautiful option for improving delicate areas such as the under-eyes, or for supporting overall skin health across the face, neck and décolletage.
We will always take a tailored approach, considering your skin condition, ageing pattern, sensitivity, lifestyle and wider treatment plan. Polynucleotides may be recommended on their own or alongside treatments such as skin boosters, microneedling, regenerative injectables or advanced skin treatments, depending on your goals.
The result is skin that looks fresher, calmer and more naturally restored, without looking over-treated.
For patients looking for polynucleotides in Hampton Bishop, Hereford — Sapphire Medical Aesthetics offers a medically led, consultation-first approach to regenerative skin treatments.
Whether you are concerned about under-eye skin, fine lines, dullness, dehydration, texture or early skin ageing, Emma will assess your skin carefully and recommend a treatment plan designed to support healthier, more resilient skin over time.
FAQ
Got Questions?
Find answers to the most common questions about polynucleotide treatments before booking your consultation.
What are polynucleotides?
Polynucleotides are injectable regenerative molecules made from purified DNA fragments. In aesthetic medicine, they are used to support skin repair, hydration, elasticity and overall skin quality.
How do polynucleotides work?
How many sessions will I need?
When will I see results?
How long do polynucleotides last?
Is the treatment painful?
Is there any downtime?
Can polynucleotides be combined with other treatments?
Are polynucleotides suitable for all skin types?
